Ashwagandha
Modulates the Hypothalamic-Pituitary-Adrenal (HPA) axis, lowering serum cortisol levels and stabilizing the nervous system response to chronic stress.
Also Known As
Indian Ginseng, Winter Cherry
Family: Solanaceae | Species: Withania somnifera | Origin: India
Medical Verification
Dr. Shilpa Thakur
ID: NUTR-SHILPA-001
Updated: May 28, 2026
Protocol Parameters
300 mg - 600 mg daily
Preferably taken in the evening or 1 hour before sleep. Standardized root extract with at least 5% withanolides.
Comparison Guide
| Form | Withanolide Content | Best Use |
|---|---|---|
| Root Powder | 1-2.5% | Moon milk, capsules, tonic drinks |
| Standardized Extract (KSM-66) | 5%+ | Clinical supplementation, sleep support |
Safety & Dosage
300-600 mg of standardized root extract (5%+ withanolides) daily, preferably evening.
- Individuals with autoimmune disorders (lupus, MS, RA)
- Those with hyperthyroidism
- Patients scheduled for major surgery within 2 weeks
- Thyroid medications (may increase T3/T4 output)
- Immunosuppressants
- Sedatives and benzodiazepines
Ayurvedic Profile
This therapeutic is configured inside custom patient plans.
Get Custom ProtocolPharmacological Profile: Ashwagandha
Withania somnifera
Primary Mechanism of Action
Modulates the Hypothalamic-Pituitary-Adrenal (HPA) axis, lowering serum cortisol levels and stabilizing the nervous system response to chronic stress.
From a biochemical standpoint, the therapeutic properties of Ashwagandha are attributed to its complex matrix of active botanical compounds. These phytochemicals interact with specific cellular receptor systems, helping to regulate physiological pathways, downregulate markers of chronic systemic inflammation, and support tissue recovery. By incorporating these compounds into circadian-aligned dietary patterns, patients can enhance functional enzyme pathways and promote metabolic recovery.
Active Phytochemical Compounds
Phytochemical analysis indicates that these primary active compounds operate synergistically to modulate cellular stress responses and promote healthy enzyme function. Supporting evidence shows that maintaining the integrity of these volatile molecules during preparation maximizes their bioavailability.
Clinical Dosage Guidelines
Consult a clinical specialist for personalized dosage targets based on biomarker analysis.
Toxicology & Precautions
Maintain safety by not exceeding recommended dosing, and verify organ clearance capability (kidney/liver) with a clinician.
Clinical Contraindications
- Autoimmune disorders (lupus, MS, RA) as it stimulates immune response
- Thyroid hyperfunction (hyperthyroidism)
- Upcoming major surgery (interacts with anesthesia)
Integrated Wellness & Circadian Biology
The therapeutic use of Ashwagandha is optimized when coordinated with your body's circadian rhythms. Integrating botanical support into designated daylight eating windows supports natural diurnal metabolic processes and helps prevent digestive stress. Aligning these choices with a high-density, whole-food diet based on our Nutritional Color Code system (NutritionColours) provides a broad range of antioxidants, supporting cellular defense and long-term health preservation.
Clinical Evidence & Citations
A randomized double-blind placebo-controlled study of Ashwagandha root extract (PMID: 31517876)
PubMed Database Link →